Fig. 1

Mining of the FDA Adverse Reporting System (FAERS) database demonstrates that dasatinib is associated with high risk for nephrotoxicity. a Workflow for FAERS database mining. b Dasatinib ranked as one of the highest reporting odds ratio (ROR) for all nephropathies among other KIs in the FAERS database. c When the KI ROR values for glomerular specific nephropathies are plotted against those for hypertension, dasatinib is seen as a clear outlier with high risk for glomerular disorder and a relatively low risk for hypertension