Fig. 10
Tumorigenicity of ODG cells is reduced by CIC re-expression or ETV5 blockade. a, b Bioluminescence imaging of NOD-SCID mice at 6 weeks post-orthotopic implantation of BT88 oligodendroglioma cells stably transfected with empty-GFP-luciferase or CIC-GFP-luciferase. Representative images a and luminescence data b from five mice per cohort. Data shown as mean ± SD. Statistical analyses by student’s t test. **p < 0.01. c, e Representative images of brain sections from mice implanted with control-GFP-luciferase BT88 cells or CIC-GFP-luciferase BT88 cells stained with H&E c or GFP e at 6 weeks post implant. Scale bars: 50 μm. d, f Representative images of brain sections from mice implanted with control-GFP-luciferase BT88 cells or DNETV5-GFP stained with H&E d or GFP f at 6 weeks post implant. Scale bars: 50 μm. g Kaplan–Meier survival analysis of mice implanted with BT88 cell transfected with empty-GFP-luciferase or CIC-GFP-luciferase. n = 5 mice per cohort. Statistical analysis by log-rank (Mantel–Cox) test; p = 0.0021. h Kaplan–Meier survival analysis for BT88 cell transfected with empty-GFP or DNETV5-GFP. n = 5 mice per cohort. Source data are provided as a Source Data file. Statistical analysis by log-rank (Mantel–Cox) test; p = 0.0018
