Fig. 5
From: Impaired cortico-striatal excitatory transmission triggers epilepsy
Impaired cortico-striatal FSI excitatory transmission in Stxbp1+/− mice. a Whole-cell recording configuration. b Representative traces of EPSCs in striatal MSNs and FSIs evoked by SSC electrical stimulations at 10 Hz. The initial EPSC responses are scaled to the dotted lines. c EPSCs showed faster rundown in FSIs (right), but not in MSNs (left), of Stxbp1+/− mice, compared to WT mice. 10 Hz stimulation [after 1000 ms stimulation, unpaired t test, WT (9 cells) vs. Stxbp1+/− (9 cells), FSI, t16 = 4.46, ***P = 0.0004]. d Steady-state levels of evoked EPSCs 1,000 ms after repetitive cortical stimulation ranging from 10 to 40 Hz. 10 MSNs and 9 FSIs, 19 slices from 9 WT mice; 10 MSNs and 9 FSIs, 19 slices from 9 Stxbp1+/− mice. Unpaired t test, WT vs. Stxbp1+/−, MSN, 10 Hz: t18 = 1.61, P = 0.128; 20 Hz: t18 = 0.4163, P = 0.6821; 40 Hz: t18 = 0.3123, P = 0.7584. FSI, 10 Hz: t16 = 4.46, ***P = 0.0004; 20 Hz: t16 = 3.277, **P = 0.0047; 40 Hz: t16 = 3.451, **P = 0.0033. Mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001
