Fig. 5
From: Molecular basis for heat desensitization of TRPV1 ion channels
Dh transition provides a feedback and protective mechanism against scald damages. a, b Withdrawal latencies of female mice in the tail-flick (n = 10, two-sided t-test: n.s., not significant) (a) and hot plate (n = 15 for WT mice, n = 7 for p-trpv1 mice, two-sided t-test: n.s., not significant) (b) assays. c Walking distance for every 3 min (50 min video-tracking) of female WT (n = 5) and p-trpv1 (n = 3) mice in the hot-plate assay, two-sided t-test: *p < 0.01. d Images of the left hind paw after six times of hot-plate assays. Red arrows indicated the phenotype of paw thickness of female mice (inset). Comparison of left hind paw thickness before and after hot-plate assays (n = 6, two-sided t-test: *p < 0.01; n.s., not significant). e–g Photomicrographs of the left hind paw sections taken from female WT (e), p-trpv1 (f), and trpv1-KO (g) mice after hot-plate assays. Note that paw thickness and tissue sections are measured from left hind paw tissue of female mice before and after six times of hot-plate assays. Scale bar, 100 μm. All statistical data are given as mean ± SEM. Source data are provided as a Source data file
