Fig. 6
From: Molecular basis for heat desensitization of TRPV1 ion channels
Dh transition avoids inflammation and cell death during sustained heat. a Levels of TNF-α, IL-β, IL-6, and IL-8 in the left hind paw tissue before and after hot-plate assays (n = 3, two-sided t-test: *p < 0.01). b Western blotting showing the absence of apoptotic-like damage in the paw tissue of p-trpv1 mice. c Time-lapse microscopy images indicating the swelling of pV1-positive cell body at 40 °C heating. mV1-positive cell body was intact at 40 °C. Scale bar, 10 μm. d The time-dependent cell volume of mV1 (n = 20) and pV1 (n = 20)-positive HEK293T cells, two-sided t-test: *p < 0.01. Note that cytokines and western blotting are measured from the left hind paw tissue of female mice before and after six times of hot-plate assays. e A cartoon illustrating Dh’s structural mechanisms and role in mammals against sustained heat. All statistical data are given as mean ± SEM. Source data are provided as a Source data file
