Fig. 9 | Nature Communications

Fig. 9

From: Inactivation of nuclear histone deacetylases by EP300 disrupts the MiCEE complex in idiopathic pulmonary fibrosis

Fig. 9

Model. a In healthy lung fibroblasts, C1D-bound MIRLET7D-ncRNA duplexes attract active HDAC1/2 and the MiCEE complex to specific loci. Active HDAC1/2 deacetylate H3K27, whereas EZH2 mediates trimethylation of H3K27, thereby leading to heterochromatin formation and transcriptional silencing. b In IPF lung fibroblasts, reduced MIRLET7D and active EP300, which inactivates HDAC1/2 and interacts with C1D, disrupt the MiCEE complex interfering with heterochromatin formation and transcriptional silencing at specific loci

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