Fig. 6 | Nature Communications

Fig. 6

From: Development of an immunodeficient pig model allowing long-term accommodation of artificial human vascular tubes

Fig. 6The alternative text for this image may have been generated using AI.

The histological analysis of the HOBPT at 3 months after transplantation in OIDPs. The graft was opened longitudinally with the proximal artery and distal vein. The red dotted line indicates the junction of the artery and graft, and the yellow dotted line indicates that of the graft and vein. The luminal surface of the HOBPT was whitish, smooth, and contiguous from the surface of the recipient’s common carotid artery and vein without thrombus a. Microscopically, the luminal surface was lined with an ERG-positive monolayer of endothelial cells b, d, e. Host-derived alpha-SMA and desmin-positive smooth muscle cells migrated into the HOBPT wall from the upper, lower and lateral margins b, c, f, g. Elastica van Gieson staining showed “neomedia” beneath the luminal surface i in the collagenous extracellular matrix and stained blue by Masson–trichrome staining h. Scale bar: 1 mm in b, c, 50 µm in d–i. HOBPT: human original 3D bioprinted tube, OIDP: operational immunodeficient pig

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