Fig. 7
From: Nucleoporin Nup155 is part of the p53 network in liver cancer
p53 status, Nup155 and FTSJ1 expression are correlated in murine and human HCC. a Murine N-rasG12V and Myc-driven HCC which developed in a Tpr53-deleted (Trp53−/−, n = 4) or -wild-type (Trp53+/+, n = 4) background were analysed by immunoblotting with the indicated antibodies. b Relative transcript levels of NUP155 (left panel) and FTSJ1 (right panel), in HCC tissue (n = 247) compared to non-tumorous liver tissue (n = 239). The center line of the box plots denotes the median, the bounds of the box indicate the 25th to 75th percentiles and the whiskers represent the 5th to 95th percentiles, respectively. ***p < 0.001 (Student′s t-test). c Correlation of NUP155 and FTSJ1 in HCC tissue (n = 247). r Pearson correlation coefficient, p Pearson p-value. d Suggested feedback loop model linking p53/p21 with Nup155 and FTSJ1. Source data are provided as a Source Data file
