Fig. 3
The association of LysoPC level and gametocyte conversion. a The total concentration of all 13 LysoPC isoforms tested is plotted for each of the samples in the 2017 high (H) (n = 10) and low (L) (n = 10) GCR cohorts and control serum from North American volunteers (n = 3) (C). Significance was determined using a Mann–Whitney test (p = 0.036). b Receiver Operating Characteristic curve was constructed for the total LysoPC concentration of each of the 2017 samples as classifiers in the high GCR (n = 10) and low GCR (n = 10) cohorts. The area under the curve was 0.78 (95% confidence interval 0.57–0.995) (p = 0.03). c Comparison of the average concentration of each of the 153 nonLysoPC metabolites in the 2017 high GCR (x axis) and the low GCR (y axis) cohorts. For each of the 153 nonLysoPC metabolites detected in the Biocrates AbsoluteIDQ ® p180 analysis the average concentration was calculated for the 10 samples in the 2017 high GCR cohort (High GCR conc) and the 10 samples in the 2017 low GCR cohort (Low GCR conc) and plotted on the x and y axes, respectively. Each dot represents one of the 153 metabolites ± s.d. The correlation coefficient (R2) and equation for the trend line are included
