Fig. 5 | Nature Communications

Fig. 5

From: In vivo nuclear capture and molecular profiling identifies Gmeb1 as a transcriptional regulator essential for dopamine neuron function

Fig. 5

Midbrain Gmeb1 knockdown results in motor impairments. a Dot plot representing mean (±s.e.m.) time (s) required for mice with midbrain knockdown of Gmeb1 or shScramble control mice to reach bottom of pole (n = 11 per group, ****p < 0.0001 in two-tailed t-test). b Dot plot representing mean (±s.e.m.) latency (s) at which mice with midbrain knockdown of Gmeb1 or shScramble control mice fall from rotarod or cling to apparatus without active locomotion (n = 11 per group, ****p < 0.0001 in two-tailed t-test). c Dot plot representing mean (±s.e.m.) score reflecting the ability of Gmeb1 or shScramble to swim over a 5-min period (n = 11 per group, ****p < 0.0001 in two-tailed t-test). d Dot plot representing mean (±s.e.m.) latency (s) at which mice with midbrain knockdown of Gmeb1 or shScramble control mice fall from horizontal wire (n = 11 per group, p = 0.3462 in two-tailed t-test)

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