Table 1 Protonation Constants of Ligands and Uranyl Chelation Stability Constants
From: A 3,2-Hydroxypyridinone-based Decorporation Agent that Removes Uranium from Bones In Vivo
Protonation Constants | EDTA(LeH4) | LcH2a | LH2 | |
|---|---|---|---|---|
pKa1 | 2.1(3) | 5.91 | 8.3(5) | |
pKa2 | 2.7(1) | 7.14 | 9.3(4) | |
pKa3 | 6.1(1) | |||
pKa4 | 9.8(1) | |||
Ligand | Species | m, l, h | Logβmlh | pUO2b |
5LIO-1-Cm-3,2-HOPO(L) | UO2LH+ | 1, 1, 1 | 24.8(7) | 16.6(5) |
UO2L | 1, 1, 0 | 18.6(7) | ||
UO2L(OH)− | 1, 1, -1 | 7.5(7) | ||
5LIO-(Me-3,2-HOPO)(Lc)a | UO2LcH+ | 1, 1, 1 | 18.4 | 15.7 |
UO2Lc | 1, 1, 0 | 14.9 | ||
UO2Lc(OH)− | 1, 1, -1 | 6.3 |
