Fig. 3 | Nature Communications

Fig. 3

From: Structural basis for human sterol isomerase in cholesterol biosynthesis and multidrug recognition

Fig. 3

Molecular mechanism of compound binding to the membrane cavity. a Details of EBP binding to U18666A. The hydrophilic interactions are indicated by dashed lines. The residues related to substrate recognition are shown as sticks. b Details of EBP binding to tamoxifen, annotated as in a. c Overall view of the membrane cavity. d Binding of EBP mutants to [3H]-Ifenprodil. Data shown are the mean ± SD of triple times determinations. Source data are provided as a Source Data file

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