Fig. 4
From: FOXF2 reprograms breast cancer cells into bone metastasis seeds
FOXF2 confers osteomimetic features on breast cancer cells and facilitates bone metastasis. a Genes coexpressed with FOXF2 in breast cancer were analyzed based on our gene expression profiling data set of 49 primary breast cancer tissues and the GOBO tool. The cutoff value of Pearson’s correlation coefficient was defined as 0.3. b The correlation of the expression of FOXF2 with BRGs in primary breast cancer tissues based on GSE20685 data set was analyzed by Pearson’s correlation analysis. c Heatmaps (top) show the correlation of the frequency of bone-only metastasis (BOM) with the expression of FOXF2 and the set of BRGs coexpressed with FOXF2 based on the GSE2034_GSE2603 data set. The score of the set of BRGs was defined as an average of the normalized intensity of each gene in all patients. d The BOM and non-bone metastasis (NBM) in the FOXF2high and FOXF2low groups and in the BRGhigh and BRGlow groups were compared. e The expression of proteins encoded by BRGs in the indicated cells was detected by immunoblot
