Fig. 1 | Nature Communications

Fig. 1

From: DNA requirement in FANCD2 deubiquitination by USP1-UAF1-RAD51AP1 in the Fanconi anemia DNA damage response

Fig. 1The alternative text for this image may have been generated using AI.

Requirement for DNA in FANCD2 deubiquitination. a Schematic of ID2 ubiquitination and deubiquitination in our reconstituted system. b ID2 was first incubated with BL100 to ubiquitinate FANCD2, followed by treatment with USP1-UAF1 without or with benzonase. The error bars represent the mean+S.D. of data from three independent experiments. c Either benzonase or DNase I treatment abolished FANCD2 deubiquitination by USP1-UAF1. The error bars represent the mean+S.D. of data from three independent experiments

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