Fig. 5
From: Fibroadipogenic progenitors are responsible for muscle loss in limb girdle muscular dystrophy 2B
Presence of AnxA2 is required for adipogenic conversion of dysferlinopathic muscle. a F4/80 staining of gastrocnemius of 12Mo WT, B6A/J and A2-B6A/J. Scale bar = 20 µm. Quantification (mean ± SD) of b F4/80 labeled area, c myofiber central nucleation, d Perilipin-1 labeled area, and e PDGFRα labeled area from 12Mo WT, B6A/J and A2-B6A/J, n = 4/genotype. Statistical comparisons performed via ANOVA with Holm–Sidak multiple comparisons test to compare all means, *p < 0.05, **p < 0.01, ***p < 0.001. f Quantification (mean ± SD) of g PDGFRα-labeled area in 6, 12, and 24Mo A2-B6A/J gastrocnemius (scale bar = 20 µm) shown in comparison to B6A/J (as presented in Fig. 2f), n = 3 mice/group. Statistical comparisons performed by two-tailed t-test between B6A/J and A2-B6A/J at each timepoint, *p < 0.05, **p < 0.01
