Fig. 6 | Nature Communications

Fig. 6

From: Adenoviral vaccine targeting multiple neoantigens as strategy to eradicate large tumors combined with checkpoint blockade

Fig. 6

GAd and checkpoint inhibitors also synergize in the MC38 tumor model. a C57BL/6 mice (n = 6/group) were immunized with a GAd vector encoding seven MC38 neoantigens (GAd-MC38-7). Two weeks post vaccination, immune responses against the seven mutated peptides were measured on splenocytes. Data are representative of two independent experiments with six mice/group for each experiment. SFC = Spot Forming Cells. b, c Efficacy of GAd-MC38-7 alone and in combination with anti-PD1 b or anti-PDL1 c. Treatment with GAd vaccine started at day 0, on mice randomized according to tumor volume. Mice showing complete tumor shrinkage post treatment are identified by black lines. Data represent at least two independent experiments (n = 8–10/group) (Fisher test. *p <0.05)

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