Fig. 4

Gene networks of IFN-associated lung modules in lung and blood across diseases. Gene networks for L5 (Type I IFN/Ifit/Oas) and L7 (Ifng/Gbp/Antigen presentation) modules depicting the “hub” genes representing genes with high intramodular connectivity, i.e., genes most connected with all other genes within the module. For each module, a representative network is shown for Toxoplasma with gene names, followed by smaller gene networks for the 6 diseases. Each gene is represented as a circular node with edges representing correlation between the gene expression profiles of the two respective genes. Color of the node represents log₂ foldchange of the gene for each disease compared to its respective controls, in the lung (left panel) and blood (right panel) samples for both modules. Pearson correlation coefficients (r) for foldchanges for all genes (disease samples compared to respective controls) in the L5 and L7 modules between lung and blood are shown