Fig. 9
From: Targeting a therapeutic LIF transgene to muscle via the immune system ameliorates muscular dystrophy
Transplantation of CD11b/LIF transgenic BMCs does not affect muscle growth or regeneration. Assays of muscle mass to body mass ratio (a), fiber number (b), proportion of centrally-nucleated regenerating fibers (c), and muscle fiber cross-sectional area (d) indicate no difference in muscle growth or regeneration between WT BMT/mdx and LIF BMT/mdx recipients. N = 5 per group. For all histograms in the figure, the bars indicate mean ± sem. e QPCR analysis shows no difference in the expression of myogenic transcription factors (Pax7, Myod1, Myog, and Mrf4) in WT BMT/mdx versus LIF BMT/mdx recipients. N = 7 or 8 for WT BMT/mdx and LIF BMT/mdx data sets, respectively. No significant differences were identified between groups at P < 0.05, determined by two-tailed t-test. Source data are provided as a Source Data file
