Fig. 1
From: m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade
FTO is upregulated in human melanoma. a Immunofluorescence staining of FTO and MART1 in normal human skin and melanoma tissues. Nuclei are counterstained with DAPI in blue. Scale bar, 50 μm. The arrows indicate representative melanocytes in normal human epidermis. b Percentage of tumors (in stacked column format) for each score of FTO. 0 (Negative), 1 (Weak), 2 (Medium), and 3 (Strong); *P < 0.05; **P < 0.01; ****P < 0.0001; ns, P > 0.05, not significant; Mann–Whitney U-test. c Immunoblot analysis of the protein levels of FTO, and β-actin (loading control) in normal melanocytes and melanoma cells
