Fig. 2 | Nature Communications

Fig. 2

From: Brain leptin reduces liver lipids by increasing hepatic triglyceride secretion and lowering lipogenesis

Fig. 2

Leptin effects on hepatic lipid metabolism are centrally mediated. a Protocol for chronic IP leptin infusion in rats (Leptin: 0.3 µg/day; same dose used in the ICV experiments; Fig. 1f). b Hepatic lipid content after 28 days IP leptin/vehicle infusion (n = 5 per group). c Protocol for tyloxapol infusion experiments in tamoxifen-inducible LpRΔPER and control mice. d Plasma TG accumulation after a tyloxapol bolus in 6 h-fasted LpRΔPER and controls (≥ 7 per group). e Hepatic VLDL secretion rate calculated from the slope in Fig. 2d. All data are mean ± SEM; no significant differences observed between leptin and control by two-tailed Student’s t test; (b) open circles: IP vehicle; black squares: IP leptin; (d, e) open circles: controls; black squares: tamoxifen-inducible leptin receptor knockout (LpRΔPER) mice

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