Table 1 Associations between baseline nasal microbiota and carriage3 outcome

From: Interaction between the nasal microbiota and S. pneumoniae in the context of live-attenuated influenza vaccine

Variable

Df

F

R 2

P value

Carriage3 outcome

2

1.79

3.07%

0.048

Month

4

0.88

3.02%

0.628

Any virus at baseline

1

0.74

0.64%

0.613

Carriage3 outcome: Vaccine

3

0.86

2.22%

0.640

Carriage3 outcome: Any virus at baseline

2

2.00

3.44%

0.011

Residuals

102

 

87.60%

 

Total

114

 

100.00%

 
  1. The association between baseline nasal microbiota composition and carriage3 outcome was adjusted for the month of sampling (i.e. seasonal effects), the presence of any virus at baseline (day −4) and the interactions between carriage3 outcome and vaccine/presence of any virus at baseline (n = 116). These interactions (indicated by a colon) were included to properly assess the associations between baseline microbiota and carriage3 outcome, the latter of which could have been impacted by viral co-infection. Analyses were performed using PERMANOVA. See Supplementary Table 3 for the detailed assessment of associations between microbiota composition and carriage2 outcome/pneumococcal density
  2. PERMANOVA permutational multivariate analysis of variance, df degrees of freedom, F F test statistic, R2 measure of variance
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