Fig. 1 | Nature Communications

Fig. 1

From: NIR-light-mediated spatially selective triggering of anti-tumor immunity via upconversion nanoparticle-based immunodevices

Fig. 1

Programming of photoactivatable immunodevice. a Schematic of the design of photoactivatable immunodevice through the integration of UCNPs with the UV light-responsive PCpG. UCNPs act as transducer to upconvert NIR light into UV light locally, thus liberate CpG ODN from PCpG to achieve the refined temporal control on its immunoactivity. b Illustration of the photoactivatable immunodevice, PCpG/UCs, for spatially selective triggering of immunoactivity through NIR light irradiation. In contrast to traditional CpG delivery system (CpG/UCs), PCpG/UCs is amenable to personalizing the anti-tumor modality with reduced systemic toxicity

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