Fig. 5 | Nature Communications

Fig. 5

From: Facilitating the transmetalation step with aryl-zincates in nickel-catalyzed enantioselective arylation of secondary benzylic halides

Fig. 5The alternative text for this image may have been generated using AI.

Substrate scope of asymmetric coupling of α-bromobenzyl trifluoromethane with lithium aryl boronates. All reaction were conducted with compound 1 (0.3 mmol), phenylboronic pinacol ester 2 (0.9 mmol), NiBr2•DME (20 mol%), ligand L2 (25 mol%) and ZnBr2 (0.3 mmol) in DME/diglyme (v/v = 1/1) at −15 °C for 12 h. Isolated yields and e.r. was determined by chiral HPLC analysis

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