Fig. 6
From: Molecular tuning of farnesoid X receptor partial agonism
NMR study on the interaction of α12 with the FXR-LBD core domain. a Model depicting transient interaction of the AF2 helix with the core domain. b Superimposition of 1H, 15N-HSQC of fully 13C/15N-labeled FXR-LBD (blue) and an AF2 truncated FXR-LBD mutant (red) reveals significant shifts and disappearance of signals indicating that α12 interacts transiently with the core domain of the FXR-LBD even in the absence of a ligand/agonist
