Fig. 2
From: Detection of cell-type-specific risk-CpG sites in epigenome-wide association studies
Association detection performance of HIRE and commonly used methods in the true alternative setting with K = 3 and n = 180. Source data are provided as a Source Data file. In all figures, red corresponds to HIRE; yellow indicates the unadjusted analysis; brown represents SVA; purple refers to RefFreeEWAS; dark blue indicates EWASher; and light blue corresponds to ReFACTor. a ROC curves of HIRE and commonly used methods. HIRE has the largest area under the curve among all of the methods. b True cell-type-specific association pattern with disease status for 10,000 simulated CpG sites; columns correspond to cell types, and the rows represent the CpG sites. Dark cells correspond to risk-CpG sites, and grey cells are CpG sites not associated with the disease status. c Detected cell-type-specific association pattern with disease status by HIRE. Darkness represents \(-{\mathrm{log}}_{10}(p - {\mathrm{value}})\) d–i The p-value density plots for association with disease status in the simulation dataset for d HIRE, e unadjusted analysis, f SVA, g RefFreeEWAS, h EWASHer, and i ReFACTor. j–o The Q-Q plots for association with disease status for j HIRE, k unadjusted analysis, l SVA, m RefFreeEWAS, n EWASHer, and o ReFACTor
