Fig. 9
From: Toxin-mediated ribosome stalling reprograms the Mycobacterium tuberculosis proteome
MazF-mt9 mechanism of action. The toxin controls gene expression through the cleavage of tRNALys43-UUU (left panel), causing ribosome stalling and subsequent degradation of the mRNAs by one or more RNases (middle panel). This cooperative action reduces the steady levels of AAA-rich proteins and favors an increase in AAA-deficient proteins (right panel)
