Fig. 9 | Nature Communications

Fig. 9

From: Tethering of vesicles to the Golgi by GMAP210 controls LAT delivery to the immune synapse

Fig. 9The alternative text for this image may have been generated using AI.

Graphical abstract: GMAP210 facilitates the delivery of vesicles containing LAT to the immune synapse. Upon TCR triggering, LAT is internalized in recycling endosomes. This endocytic pool of LAT is “retrotransported” to the Golgi apparatus24, where it meets the vesicular SNARE VAMP7 that is involved in LAT trafficking13. GMAP210, which binds the Golgi through Arf1, sorts and captures the LAT/VAMP7 vesicles via its N-terminal domain (inset). The long coiled-coil domain of GMAP210 then brings LAT-containing vesicles close to the immune synapse

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