Fig. 3 | Nature Communications

Fig. 3

From: Patient-specific cancer genes contribute to recurrently perturbed pathways and establish therapeutic vulnerabilities in esophageal adenocarcinoma

Fig. 3

Features of EAC clusters driven by pathways enriched in helpers. a For each helper cluster (1H-6H) indicated are the molecular features (mutational signatures, number of genes with damaging mutations, undergoing amplification or deletion), the distribution of stage 2 tumours and the tobacco smoking habits of the patients that show significant associations with one of the six clusters of helpers. Enrichment in number of altered genes, tumour staging, smoking habits and cancer predisposition was assessed using Fisher’s exact test. Distributions of mutational signatures were compared using Wilcoxon rank-sum test. FDR = false discovery rate after correction for multiple testing. b Kaplan–Meier survival curves of EACs in cluster 4H (n = 37) and the rest of EACs (n = 224). Analysis was performed using survival (https://github.com/therneau/survival) and survminer (https://github.com/kassambara/survminer) R packages with default parameters. Significance was measured using the log-rank test

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