Fig. 5
From: AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders
Agonist-evoked currents in HEK cells. 1 mM KA was applied transiently to HEK cells expressing GluA2 and stargazin (a), or GluA1, GluA2 and stargazin (b). Amplitude was compared to WT (*p < 0.05, **p < 0.01, ***p < 0.001) and for co-expression also to the negative control (GluA1 without GluA2, —, #p < 0.05, ##p < 0.01, ###p < 0.001). Mean ± SEM. Data are from the following numbers of independent cells: (a) WT:25, G47E:7, D302G:6, P528T:7, Δ528–530:11, Q607E:10, G609R:13, D611N:8, A639S:10, F644L:6, T646N:10, V647L:10 (b) —:21, WT:28, G47E:7, D302G:10, P528T:9, Δ528–530:15, Q607E:12, G609R:11, D611N:15, A639S:19, F644L:14, T646N:12, and V647L:6
