Fig. 7
From: AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders
Changes at the polyamine binding site alter rectification in GluA2 homomeric channels. a Pore detail of 2 opposing subunits in GluA2 tetramer (cryo-EM structure pdb 6dm0). b Ramps were applied to HEK cells expressing homomeric GluA2 channels and rectification quantified as for Fig. 4 (*p < 0.05, **p < 0.01, ***p < 0.001). Number of cells recorded per mutant: WT:6, Q607E:7, D611N:3
