Fig. 2
From: Structure of the substrate-engaged SecA-SecY protein translocation machine
The interaction between SecA and SecY and changes in SecY’s plug domain. a Interaction of the loop between TMs 6 and 7 of SecY (L6/7) (red) with the PPXD (blue), the THF, and the loop between TMs 8 and 9 (L8/9). The regions involved are colored yellow. b Interaction of the C-terminal tail (yellow) of SecY with SecA. SecA is shown as a space-filling model with residues colored according to their hydrophobicity. Interacting SecY residues are shown as yellow sticks. c Comparison between the plug regions in the cryo-EM structure and the crystal structure of SecA-OAins/SecY (PDB ID: 5EUL). The SecY molecule and plug are colored salmon and yellow, respectively, for the cryo-EM structure, and cyan and green, respectively, for the crystal structure. d Top view of (c)
