Fig. 4
From: Chemical logic of MraY inhibition by antibacterial nucleoside natural products
A detailed view of the interactions between MraYAA and 3′-hydroxymureidomycin A. a The binding pockets recognized by 3′-hydroxymureidomycin A (bright green) on the cytoplasmic side of MraYAA include the uridine (red), uridine-adjacent (lime green), TM9b/Loop E (purple), and Mg2+ (gold) sites. b A zoomed-in view of the 3′-hydroxymureidomycin A binding site in the same orientation as shown in a. Residues forming interactions with 3′-hydroxymureidomycin A are labeled and color-coded according the binding pocket to which they belong. Hydrogen bonds are represented by dashed lines. c A view of the 3′-hydroxymureidomycin A binding site rotated 45° relative to the orientation shown in a. TMs (numbers) and Loops (letters) are labeled throughout. The side chain of residue K70 is disordered in the MraYAA-3′-hydroxymureidomycin A complex structure
