Fig. 2 | Nature Communications

Fig. 2

From: Brain somatic mutations observed in Alzheimer’s disease associated with aging and dysregulation of tau phosphorylation

Fig. 2

Mutation signatures of brain and blood somatic mutations in Alzheimer’s disease (AD). The best decomposed mutation signature models from multiple likelihood estimation were derived for each tissue along with actual distribution of 96 possible mutation types. a Single base substitution (SBS) signatures 5, 1, and 18 and others account for 23.6%, 15%, 22.2%, and 39.2% of brain somatic mutations in AD, respectively. b SBS signatures 5 and 1, and others account for 71.0%, 19.8%, and 9.2% of blood somatic mutations in AD, respectively

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