Table 1 Summary of baseline characteristics of enrolled subjects

From: Brain somatic mutations observed in Alzheimer’s disease associated with aging and dysregulation of tau phosphorylation

Category

AD

non-AD

No. of individuals

52

11

Gender

16 M; 36 F

7 M; 4 F

Age, mean ± SD (range)

83.06 ± 7.96 (70–96)

74.09 ± 9.43 (57–89)

Onset age, mean ± SD (range)

73.18 ± 11.67 (48–94)

–

Braak tau, mean ± SD (range)

4.65 ± 1.31

0.45 ± 0.52

 #High (4–6)

85% (44/52)

0% (0/11)

 #Low (0–3)

15% (8/52)

100% (11/11)

Family historya

23% (12/52)

9% (1/11)

APOE ɛ4 genotype (%)

  ɛ4/ɛ4

15.4% (8/52)

9.1% (1/11)

  ɛ4/−

48.1% (25/52)

18.2% (2/11)

  −/−

36.5% (19/52)

72.7% (8/11)

  1. AD Alzheimer’s disease, non-AD control unaffected by AD, APOE apolipoprotein E
  2. aPositive family history indicates subjects having at least one first- or second-degree relative diagnosed with AD
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