Fig. 1
From: Activation of STAT3 signaling is mediated by TFF1 silencing in gastric neoplasia
Loss of TFF1 promotes STAT3 nuclear localization in the TFF1-KO mice gastric tissues. a Representative immunohistochemistry images in the upper panels show nuclear p-STAT3 (Y705) in hyperplasia, dysplasia, and cancer from the antropyloric region of glandular stomach in TFF1-knockout (TFF1-KO), but not in TFF1-wild-type (TFF1-WT) normal gastric mucosa. The lower panels demonstrate the expression of TFF1, original magnification (×200) and insets (×400). b Immunohistochemistry staining of p-STAT3 of gastric mouse tissues from TFF1-WT and TFF1-KO mice at the age of 2, 6, and 10 months detected p-STAT3 in the nucleus at all ages in TFF1-KO mice. p-STAT3 staining was absent in tissues from matched ages in TFF1-WT mice with normal glands. The TFF1-KO mice showed dysplastic lesions at 6 and 10 months of age. Original magnification (×400) and insets (×600)
