Fig. 3
From: Neuroepigenetic signatures of age and sex in the living human brain
HDAC1 and HDAC2 expression is increased in the white matter of elderly donors. Whole-cell lysates were prepared from post mortem periventricular white matter and corpus callosum tissues. Protein expression of HDAC paralogs (1, 2, 3, and 6) were compared between younger donors (n = 9, 16–21 years -old) and older donors (n = 9, 76–100-years-old) by western blotting (two-tailed unpaired t-test; false discovery rate (FDR) corrected for multiple comparisons). For each paralog, immunoreactive band intensity was normalized by GAPDH and scaled to a mean of 1. Box plots display median, first quartile, third quartile, and range (min–max) from a, b periventricular white matter and c corpus callosum. See Supplementary Figs. 10 and 11 for western blot images
