Fig. 4

[¹¹C]Martinostat uptake shows sex-specific differences. Voxel-wise comparison of SUVR between females (n = 20) and males (n = 21), controlled for age, total grey matter volume/intracranial volume, white matter volume/intracranial volume and cerebrospinal fluid volume/intracranial volume. Statistical maps were overlaid onto the MNI 1 mm template in radiological orientation (two-tailed unpaired t-test; Z > 2.3, P_Cluster < 0.05). Red–yellow represents regions significantly increased in females compared to males and blue-light blue represents regions significantly decreased in females compared to males