Fig. 5
From: Eradication of unresectable liver metastasis through induction of tumour specific energy depletion
Pharmacokinetic analysis. a The bio-distribution profiles of Mito(T)-pep-Nuc(T). Mice bearing DLM were injected intravenously with Mito(T)-pep-Nuc(T) before sacrificed at different time points. Four organs including liver, spleen, kidneys, and lungs were collected in addition to blood sample. The violin plot outlines illustrate kernel probablity density, with the area revealing the population of located data. Data are presented as mean ± s.e.m. (n = 3). b, c Necropsy images of liver tissues bearing b HCC and c DLM. These tissues were sampled as I to III, followed by processing and analyses individually. d, e shows the flow-cytometry results of cancer cells and Kupffer cells enriched from the single cell suspension produced from d HCC and e DLM. In each graph, the upper row displays the histogram of enriched cells, with the lower row lays the same control cells received no treatment. A cartoon was given right to d and e, wherein the simplified pathological features of HCC and DLM were shown. f, g The averaged results of fluorescence intensity change (Ce6) in a fold of change fashion for f HCC and g DLM model, respectively. Data are presented as mean ± s.e.m. (n = 3). P values were calculated by Student’s t-test (***p < 0.005)
