Fig. 2

Structural variant complexity. a Five rearrangement signatures (RS) were identified. Rearrangements were classified into 32 categories based on the rearrangement size, type (Del = deletion, Dup = duplication, Inv = inversion, T = translocation) and whether breakpoints are clustered (left) or non-clustered (right). b Two groups of tumors following clustering with ConsensusClusterPlus. Plots from top to bottom are: number and type of SVs; proportion of each rearrangement signature (light blue = lower, dark blue = higher); evidence of localized complexity per chromosome, per sample (light = lower, dark = higher); number of kataegis loci per chromosome, per sample; total number of kataegis loci per sample; tumor ploidy; tumor purity; sample origin, sample ancestry, tumor body site, and body region