Fig. 2
From: Analysis of polygenic risk score usage and performance in diverse human populations
Forest plot of performance shows variation in polygenic score performance by ancestry (26 studies). Each row in the forest plot (left) represents one pair of polygenic analyses (i.e., in a non-European ancestry sample and a matched European ancestry sample from the same study. Phenotypes, citation information, and available effect sizes are given for each comparison. The vertical black line at 100% corresponds to equal performance in the non-European ancestry and the European ancestry samples. Vertical colored lines denote median standardized effect sizes, for each of the major ancestry groups. On the top right, median values for standardized effect sizes, for each major ancestry group, are given. Standard errors are not provided because many studies lacked sufficient information; however, statistical significance of each non-European ancestry analyses is denoted by point size. HDL-C high density lipoprotein cholesterol, VLDL very low-density lipoprotein, GERA Genetic Epidemiology Research on Aging, OR odds ratio, UKB UK Biobank, IgAN immunoglobulin A nephropathy, AUC area under the curve, BP blood pressure, BMI body mass index
