Fig. 3
From: Analysis of polygenic risk score usage and performance in diverse human populations
Polygenic score distributions vary by ancestry and methodical choices. For polygenic score construction, clumping is often used, and investigator-driven choices can produce large differences in score distributions for global populations. Polygenic score distributions for the five major 1000Genomes populations are plotted, showing how investigator-driven choices impact score distributions. For all plots, weights were derived from the UK biobank height GWAS. Both r2 values used in clumping (r2 = .2, .05, .01; see columns) and 1000Genomes populations used for clumping were varied (ALL, EUR, AFR, AMR, EAS, SAS; see rows). a, b correspond to the p-value threshold (pT) applied to the height summary statistics. a pT = genome-wide significant variants (p < 5 × 10−8); b pT = full genome variants (p < 1). PRS=polygenic risk score. ALL union of five 1000Genomes populations
