Fig. 4

Scatterplots of height polygenic scores (x-axis) and phenotypic height (y-axis). Plots demonstrate that correlations between polygenic scores for height and height are not consistent across discovery GWAS. The y-values for height are the same for each plot and reflect average height of individuals in the country of origin for each population included. Average heights (y-axis) are from a different height GWAS used to construct polygenic scores (x-axis). Three different GWAS of height were used (i.e., three rows) with three different p-value thresholds (i.e., three columns) for the construction of polygenic scores. a GIANT-based polygenic scores for height. b UK Biobank-based polygenic scores for height. c East Asian based polygenic scores for height. The last two plots are missing because only genome-wide significant variants were available for the East Asian GWAS of height. p and r values for each plot are for correlation tests between polygenic scores for height (x-axis) and height (y-axis). GWAS=genome-wide association study, GIANT=Genetic Investigation of ANthropometric Trait, PRS=polygenic risk score, population abbreviations within scatterplots are those used by the 1000Genomes Consortium and are available in Supplementary Table 3