Fig. 4 | Nature Communications

Fig. 4

From: Artificial cysteine-lipases with high activity and altered catalytic mechanism created by laboratory evolution

Fig. 4

The binding modes and surface representation of substrate 1 in CALB and its mutants. The structures were obtained from cluster analysis of the 100-ns MD trajectory. a and e, WT CALB after 15 ns of MD simulation. b and f, Variant QW2. c and g, Variant QW10. d and h, Variant QW4. Loop 137–150 is shown in red cartoon and surface. Helix 277–288 is shown in blue cartoon and surface. Substrate 1 is shown as a red sphere

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