Table 2 Stereoselectivity of hydrolytic kinetic resolution of rac-15

From: Artificial cysteine-lipases with high activity and altered catalytic mechanism created by laboratory evolution

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Entry

Enzyme

Reaction time (h)

Conv. (%)

eep (%)

E

1

WT

24

49

93

83 (R)

2

QW1

36

6

56

4 (R)

3

QW4

36

31

93

41 (S)

4

QW10

36

18

93

33 (S)

5

W104A

24

48

82

23 (S)

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