Fig. 1

Genome-wide association study of neurological protein biomarkers. a Chromosomal locations of pQTLs. The x-axis represents the chromosomal location of conditionally significant cis and trans SNPs associated with the levels of Olink® neurology proteins. The y-axis represents the position of the gene encoding the associated protein. Cis (red circles); trans (blue circles). b Significance of sentinel cis variants versus distance of variants from the gene transcription start site. c Absolute effect size (per standard deviation of difference in protein level per effect allele) of conditionally significant pQTLs versus minor allele frequency. Cis (red circles); trans (blue circles). d Variance in protein levels explained by conditionally significant pQTLs. It is important to note that these estimates may be inflated owing to winner’s curse or over-fitting in the discovery GWAS. e Classification of pQTL variants by function as defined by functional enrichment analysis in FUMA. f Number of conditionally significant pQTL variants per Olink® neurology protein