Table 1 Summary of cell specificity for 26 traits
From: Genetic mapping of cell type specificity for complex traits
Trait | Datasetsa | Step 1b | Step 2c | Step 3d | Summary of independent cell typese |
|---|---|---|---|---|---|
Cardiovascular | |||||
CAD | 14 | 68 | 16 | 4 | Endothelial cell, astrocytes and muscle cells |
DBP | 13 | 31 | 16 | 3 | Endothelial cell and brain pericyte |
HBP | 15 | 45 | 19 | 3 | Endothelial cell, brain pericyte and oligodendrocyte |
PR | 7 | 11 | 8 | 4 | Cardiac muscle cell, smooth muscle cell, endothelial cell and mural cell |
SBP | 15 | 53 | 17 | 2 | Endothelial cell and oligodendrocyte precursor cell |
Immunological | |||||
IBD | 22 | 104 | 25 | 4 | Microglia, blood cell, endothelial cell and marrow B-cell |
MS | 8 | 15 | 10 | 4 | Marrow B-cell, microglia, professional antigen-presenting cell and dendritic cell |
RA | 17 | 61 | 19 | 5 | Marrow B-cell, blood cell, microglia and professional antigen-presenting cell |
SLE | 10 | 23 | 12 | 3 | Mammary macrophage, lung B-cell and microglia |
T1D | 5 | 15 | 5 | 3 | Marrow B-cell, endothelial cell and microglia |
Metabolic | |||||
BF | 0 | 0 | − | − | − |
BMI | 17 | 147 | 20 | 4 | 4 cluster of neurons |
CKD | 0 | 0 | − | − | − |
OB | 4 | 14 | 5 | 5 | 5 cluster of neurons and leukocyte |
WHR | 21 | 187 | 25 | 6 | Endothelial cell, mesenchymal cell, vascular smooth muscle and outer bulge |
Cognitive | |||||
EA | 16 | 180 | 20 | 5 | 5 clusters of neurons |
IQ | 16 | 220 | 18 | 4 | 4 clusters of neurons |
Neurological | |||||
AD | 3 | 3 | − | 3 | Monocyte and microglia |
EPL | 0 | 0 | − | − | − |
ISM | 1 | 1 | − | − | Substantia innominate |
IV | 0 | 0 | − | − | − |
Psychiatric | |||||
ADHD | 0 | 0 | − | − | − |
MDD | 1 | 1 | − | − | Inhibitory neuron |
NEU | 13 | 87 | 15 | 5 | 5 clusters of neurons and pars tuberalis |
SCZ | 20 | 187 | 25 | 5 | 5 clusters of neurons |
SWB | 1 | 1 | − | − | Layer 5 intratelencephaic neuron |
