Fig. 5 | Nature Communications

Fig. 5

From: Stereoselective synthesis of medium lactams enabled by metal-free hydroalkoxylation/stereospecific [1,3]-rearrangement

Fig. 5

Reaction scope for kinetic resolution of racemic 1. Reaction conditions: 1 (0.1 mmol), Cat. 3 (0.02 mmol), Et2O (2 mL), 25 °C, 6–32 h, then Et3N (0.03 mmol), PhCl (1 mL), 60 °C, 24 h, in vials; yields are those for the isolated products; e.r.s are determined by high-performance liquid chromatography (HPLC) analysis on a chiral stationary phase

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