Table 1 Distribution of subjects and frequency of responders in this study

From: Repeat vaccination reduces antibody affinity maturation across different influenza vaccine platforms in humans

Influenza subtype

#Seroneg @ Day 0a, n (%)

Responders (≥4-fold increase)c, n (%)

#Seropos @Day 0b, n (%)

Responders (≥4-fold increase)c, n (%)

#Seroneg @Day 0a, n (%)

Responders (≥4-fold increase)c, n (%)

#Seropos @Day 0b, n (%)

Responders (≥4-fold increase)c, n (%)

FluBlok

 

Year 1 (n = 10)

Year 2 (n = 22)

H1

3 (30%)

3 (100%)

7 (70%)

6 (86%)

4 (18%)

2 (50%)

18 (82%)

13 (72%)

H3

3 (30%)

3 (100%)

7 (70%)

6 (86%)

1 (5%)

1 (100%)

21 (96%)

10 (48%)

B

3 (30%)

1 (33%)

7 (70%)

4 (57%)

7 (32%)

1 (14.3%)

15 (68%)

3 (20%)

FluCelvax

 

Year 1 (n = 12)

Year 2 (n = 26)

H1

4 (33%)

4 (100%)

8 (67%)

4 (50%)

2 (8%)

2 (100%)

24 (92%)

13 (54%)

H3

3 (25%)

2 (67%)

9 (75%)

6 (67%)

2 (8%)

2 (100%)

24 (92%)

15 (63%)

B

3 (25%)

2 (67%)

9 (75%)

2 (22%)

6 (23%)

5 (83%)

20 (77%)

3 (15%)

Fluzone

 

Year 1 (n = 9)

Year 2 (n = 22)

H1

0 (0%)

0 (0%)

9 (100%)

5 (56%)

0 (0%)

0 (0%)

22 (100%)

5 (23%)

H3

6 (67%)

6 (100%)

3 (33%)

3 (100%)

2 (9%)

1 (50%)

20 (91%)

4 (20%)

B

3 (33%)

3 (100%)

6 (67%)

3 (50%)

5 (23%)

1 (20%)

17 (77%)

4 (24%)

  1. aSeronegatives are defined as individuals with pre-vaccination (Day 0) HI titers of <40
  2. bSeropositives are defined as individuals with pre-vaccination (Day 0) HI titers of >40
  3. cResponders are defined as >4-fold increase in post-vaccination (Day 28) titers over pre-vaccination (Day 0) titers