Fig. 6
From: Standard screening methods underreport AAV-mediated transduction and gene editing
Ai14xSpcas9 mice capture AAV8-CRISPR-Cas9 editing across tissues. a AAV8-ROSA-gRNAs vector edits the ROSA26 locus and activates tdTomato expression in Ai14xSpCas9 mice. b Representative photomicrographs of tissue from Ai14xSpCas9 mice at 2 weeks post IV delivery of 2.3e11 vg AAV8-ROSA-gRNAs per mouse. tdTomato expression (red) and nuclei (blue) are shown. n = 3 Ai14xSpCas9 mice. Scale bars = 100 µm
