Fig. 8
From: Mitofusins regulate lipid metabolism to mediate the development of lung fibrosis
Impaired fatty acid synthesis in AEC2 cells promotes bleomycin-induced lung fibrosis. a Schema outlining the generation of mice with tamoxifen-inducible Fasn knockout in AEC2 cells. b Immunoblots showing MFN1, MFN2, TIM23 and β-actin expression in AEC2 cells from control or FasniΔAEC2 mice (n = 3 mice per group). c–e Kaplan–Meier survival curves (control n = 9, FasniΔAEC2 n = 9; *p < 0.05, by log-rank test) (c), body weight changes (control n = 27, FasniΔAEC2 n = 22) (d) and acid-soluble collagen depositions in right lung (control n = 7, FasniΔAEC2 n = 4) after bleomycin treatment (e) (d, e the line indicates mean; *p < 0.05, by unpaired Student’s t test). f Representative Masson’s Trichrome-stained lung sections (200X magnification; scale bar 200 μm) of mice 14 days after bleomycin treatment (n = 5 mice per group). Source data (b–e) are provided as a Source Data file
